Role and Regulation of SP-D

Allergen inhalation elicits characteristic inflammatory changes in susceptible patients while normal individuals remain symptom-free. The exact mechanisms that ensure both elimination of inhaled allergenic material and protection of the lung from an inappropriate immune response are unknown. The long-term goal of my research is to unravel the crosstalk between the innate and adaptive immune system during development of allergic and infectious inflammatory changes in the lung. To investigate T-cell related pathologies such as the allergic airway response my laboratory has established various in vitro and in vivo (rodent) model systems suitable to study pulmonary inflammation as well as the resulting changes in lung physiology. My laboratory is one of the few that study the importance of the pulmonary surfactant and in particular, the lung collectins, (SP-A and SP-D), in asthma and chronic obstructive pulmonary disease. Our observations support the novel concept that these lectin-like molecules play an essential protective regulatory role during inflammatory changes. These findings are important because they may provide unique, novel therapeutical opportunities to control and manipulate the immune system in the lung.

Angela Haczku
Suite 1209
125 S 31st Street
Philadelphia, PA 19104-3403
phone: +1 (215) 573-4718
fax: +1 (215) 746-1224