Coronary artery disease (CAD) occurs when the arteries that supply blood to the heart muscle become hardened and narrowed. The arteries harden and narrow due to buildup of plaque. Plaque buildup is known as atherosclerosis. Angina is chest pain that occurs when the heart does not get enough blood. Clinical research involves investigations into the molecular, genetic and environmental causes of coronary artery disease, new therapies to treat patients with coronary artery disease and/or angina pectoris, new modalities to detect, quantify and diagnose coronary artery disease, vulnerable plaques, and regression of coronary artery disease.
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