Heart failure is a condition in which the heart cannot pump enough blood throughout the body. Heart failure develops over time as the pumping action of the heart grows weaker. Persons with very severe heart failure may be considered for a mechanical heart pump or a heart transplant. Clinical research involves investigations into the molecular, genetic and environmental causes of congestive heart failure and cardiomyopathy. Also includes: new therapies to treat patients diagnosed with heart failure including medical, surgical and biological therapies, heart transplantation, ventricular assist devices and other mechanical therapies including cardiac re-synchronization (CRS) therapy.