»Cardiovascular Clinical Trials 

Protocol
            
804768

Title
            
TOPCAT: Treatment of diastolic heart failure with medication

Official Title
            
Treatment of Preserved Cardiac Function Heart Failure with Aldosterone-antagonist (Amended Protocol, Version 1.7, June 04, 2009)

Investigator
            
Thomas Cappola, MD,ScM

Status
            
Recruiting

Why is this study being done?
            
This study is being conducted to see if adding a drug called spironolactone will help patients with diastolic heart failure.

Who is eligible to participate in this study?
            Inclusion
To be elibible for this study, subjects need to have heart failure with an ejection fraction greater than or equal to 45% as measured by an echocardiogram.

Age range?
            From:
50

What is involved with this study?
            
Subjects will be randomized to either the study drug or placebo. Subjects will be expected to attend office visits. Follow-up safety labs will be drawn at each office visit.

How long will this study run?
            
This is a large NIH funded study and the duration for participation will be 4.5 years. Planned office visits will occur every four months during the first year and every six months thereafter.

Who can I contact for additional information on this trial?
            Name:
Judy Marble, RN, MS
            Phone:
(215)615-0830
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